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The inclusion of glycerol in HA is based on results about aquaglyceroporin AQP3 in mammalian skin epidermis keratinocytes. Mice missing AQP3 exhibit dry pores and skin and reduced stratum corneum hydration,膠原蛋白針又被稱為「熊貓針」,主要成分是第一型膠原蛋白atelocollagen,也就是人體最豐富的膠原蛋白種類